RNA‐binding proteins implicated in neurodegenerative diseases
作者： Mark R Cookson
DOI: 10.1002/WRNA.1397
关键词:
摘要: Gene expression is regulated at many levels, including after generation of the primary RNA transcript from DNA but before translation into protein. Such post-translational gene regulation occurs via action a multitude binding proteins and include varied actions splicing to association with translational machinery. Primary evidence that such processes might contribute disease mechanisms in neurodegenerative disorders comes observation mutations proteins, particularly diseases amyotrophic lateral sclerosis-frontotemporal dementia spectrum some forms ataxia tremor. The bulk recent surveys types species are affected these suggests global deregulation control rather than very small number species, although why groups neurons sensitive changes not well understood. Overall, data suggest neurodegeneration can be initiated by and, as corollary, loss post-transcriptional level. observations have implications only for understanding nature also how we intervene therapeutically diseases. WIREs 2017, 8:e1397. doi: 10.1002/wrna.1397 For further resources related this article, please visit website.
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