Maspin is a PTEN-Upregulated and p53-Upregulated Tumor Suppressor Gene and Acts as an HDAC1 Inhibitor in Human Bladder Cancer
作者： Yu-Hsiang Lin , Ke-Hung Tsui , Kang-Shuo Chang , Chen-Pang Hou , Tsui-Hsia Feng
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摘要: Maspin is a member of the clade B serine protease inhibitor superfamily and exhibits diverse regulatory effects in various types solid tumors. We compared expressions maspin determined its potential biological functions mechanisms bladder carcinoma cells vitro vivo. The results RT-qPCR indicated that expressed significantly lower levels cancer tissues than paired normal tissues. immunohistochemical assays human tissue arrays revealed similar results. Maspin-knockdown enhanced cell invasion whereas overexpression resulted opposite process taking place. Knockdown also tumorigenesis vivo downregulated protein acetyl-histone H3. Moreover, cells, modulated HDAC1 target genes, including cyclin D1, p21, MMP9, vimentin. Treatment with MK2206, which an Akt inhibitor, upregulated expression, PTEN-knockdown or PTEN activity (VO-OHpic) treatments demonstrated reverse ectopic p53 camptothecin treatment induced expression. Our study PTEN-upregulated p53-upregulated gene blocks growth vivo, may act as cells. consider tumor suppressor cancer.
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