Cyto-histologic agreement in pathologic subtyping of non small cell lung carcinoma: review of 602 fine needle aspirates with follow-up surgical specimens over a nine year period and analysis of factors underlying failure to subtype.

摘要: Abstract Background The differential therapeutic efficacy and toxicity of targeted therapies has made subtyping non-small lung cancer (NSCLC) mandatory. This study aimed to review the accuracy NSCLC using fine needle aspirates (FNAs) in two periods (before after introduction therapy), checking reasons for failure impact use immunohistochemistry (IHC). Methods An electronic search retrieved all FNAs with a corresponding surgical specimen from 2001 2009. NSCLC, NOS (not otherwise specified) cases 2005 2009 (after therapy) were reviewed determine further subtype based solely on cytomorphology. number which IHC was performed antibodies used also recorded. Results Cytohistological agreement 602 (341 adenocarcinomas, 93 squamous cell carcinomas 168 NOS) achieved 93.80%. There significant decrease percentage not subtyped period therapy (35.07% versus 24.57%). Final morphological 17.03%. 157 cases, an increased recent years. did influence overall success average 3 markers used. Most frequent TTF-1, CK7, high molecular weight keratin p63. More than half even corresponded poorly or undifferentiated neoplasms specimens. For performed, block produced 106 (75.71%). Review slides showed that majority (70.7%) had rare, few no tumor cells. Conclusions Specific can be proportion accuracy. significantly decreased years together trend as well blocks produced. subtyping.