Tetra-substituted phenyl derivatives

摘要: Compounds of general formula (1): ##STR1## are described wherein ═W-- is (1) ═C(Y)-- where Y a halogen atom, or an alkyl, --Xa R1 group Xa --O--, --S(O)m -- m zero integer value 1 2!, --N(Ra)-- Ra hydrogen atom optionally substituted alkyl group! and or, (2) ═N--; X as above for chain --CR═C(Rb)-- --CH(R)!q --CH(Rb)-- R fluorine methyl group, Rb below R2 q the 1; alkenyl, cycloalkyl cycloalkenyl when --N(Ra)--; atoms groups; R3 R13 ; R4 defined R6 R5 atom; --(CH2)n Ar R8, which may be same different, straight branched group; salts, solvates, prodrugs, hydrates N-oxides thereof. according to invention phosphodiesterase type IV inhibitors useful in prophylaxis treatment disease such asthma unwanted inflammatory response muscular spasm present.