The Intertwined Roles of Transcription and Repair Proteins

摘要: Transcription is apparently risky business. Its intrinsic mutagenic potential must be kept in check by networks of DNA repair factors that monitor the transcription process to lesions could otherwise compromise transcriptional fidelity and genome integrity. Intriguingly, recent studies point an even more direct function complexes as coactivators unexpected role "scheduled" damage/repair at gene promoters. Paradoxically, spontaneous double-strand breaks also induce ectopic essential for repair. Thus, transcription, damage, may physically functionally intertwined than previously appreciated.