Association between the expression of chemokine receptors CCR7 and CXCR3, and lymph node metastatic potential in lung adenocarcinoma

摘要: Chemokines and their receptors are essential for leukocyte trafficking, also involved in cancer metastasis to specific organs. Although the migration of tumor cells into lymph nodes is an important aspect cancer, processes poorly understood. Chemokine CCR7 CXCR3 have been shown play role cell node metastasis. Therefore, assessment chemokine receptor expression on lung adenocarcinomas may improve prediction spread this carcinoma nodes. In study, we examined function these two (CCR7 CXCR3) adenocarcinoma. By using flow cytometry, they were detected all adenocarcinoma lines examined. chemotaxis assays, A549 exhibited CCL21-induced migration, which was significantly suppressed by neutralizing anti-CCR7 antibody. The CXCL10-induced anti-CXCR3 clinical samples, found 65 90% cases, respectively, most had Importantly, associated with metastasis, although not. These results suggest that activation ligands preferentially stimulates draining