Arginine Vasopressin and Oxytocin Modulate Human Social Behavior

摘要: Increasing evidence suggests that two nonapeptides, arginine vasopressin and oxytocin, shape human social behavior in both nonclinical clinical subjects. Evidence is discussed autism spectrum disorders genetic polymorphisms the vasopressin-oxytocin pathway, notably receptor 1a (AVPR1a), oxytocin (OXTR), neurophysin I II, CD38 (recently shown to be critical for by mediating secretion) contribute deficits socialization skills this group of patients. We also present first expression lymphoblastoid cells derived from subjects diagnosed with correlated skill phenotype inventoried Vineland Adaptive Behavioral Scales. Additionally, we discuss molecular AVPR1a OXTR genes prosocial or altruistic experimental paradigms, dictator game values orientation. The role analyzed prepulse inhibition. Prepulse inhibition startle response auditory stimuli a largely autonomic resonates cognition animal models humans. First results are presented showing intranasal administration increases salivary cortisol levels Trier Social Stress test. To summarize, accumulating studies employing broad array cutting-edge tools psychology, neuroeconomics, genetics, pharmacology, electrophysiology, brain imaging beginning elaborate intriguing behavior. expect future will continue advance deepen our understanding these complex events.