Comparison of 5 intravenous lipid emulsions and their effects on hepatic steatosis in a murine model

摘要: Abstract Background Plant-based intravenous lipid emulsions have been shown to contribute parenteral nutrition–associated liver disease (PNALD). There is mounting evidence that fish oil–based may prevent this injury. This study compares 5 with different fat compositions and their effect on hepatic steatosis, one of the first hits in PNALD. Methods C57BL/6J mice were placed a fat-free diet randomized into equal groups. Each group received commercially available (Intralipid [Baxter/Fresenius Kabi, Deerfield, Ill], Liposyn II [Hospira Inc, Lake Forest, ClinOleic [Baxter/Clintec Parenteral SA, Cedex, France], SMOFlipid [Fresenius Bad Homburg, Germany], or Omegaven Kabi Deutschland GmbH]) normal saline. Liver enzymes, degree fatty acid analyzed after 19 days. Results Intralipid, II, ClinOleic, groups all demonstrated moderate steatosis contents 17.4%, 21.9%, 22.5%, 12.6%, respectively. mice, however, had livers. Saline control developed biochemical essential deficiency (EFAD). Lipid supplementation prevented onset EFAD, whereas administration did not. Conclusion The emulsion EFAD murine model. ω -3 acids be efficacious preventing PNALD should explored development novel emulsions.