Performance of a shortened Scale for Assessment of Positive Symptoms for Parkinson's disease psychosis.

摘要: Abstract Background Parkinson's disease psychosis is a frequent and serious complication of advanced disease, but few disease-specific outcome measures exist. Methods Using baseline scores from 4 clinical trials, we identified relevant items that assessed to create shortened version the Scale for Assessment Positive Symptoms. We then analyzed validity treatment sensitivity scale. Principal component analyses evaluated underlying structure. Scores were compared across age, gender, trial, cognition, country origin. Sensitivity change was by comparing in global impression improvement score, effect sizes calculated evaluate response. Results Nine selected based on face-validity symptom frequency. analysis yielded 4-factor structure delusions visual, auditory, somatic hallucinations as distinct constructs. Baseline total similar study, region, age group. The clinically meaningful scale, defined 1-unit impression, 2.33 points, size was −0.722. did not significantly differ between those with cognitive impairment without. Conclusions Symptoms retains reliability, change, larger scale while reducing administration time and, more importantly, score variability. an effective measure use trials.