Abatement of cockroach allergen (bla g 1) in low-income, urban housing: A randomized controlled trial

摘要: Abstract Background: Clinically relevant reductions in exposure to cockroach allergen, an important risk factor for asthma inner-city households, have proven difficult achieve intervention trials. Objective: This study investigated a method the abatement of allergen low-income, urban homes. The goal was reduce mean Bla g 1 concentrations below previously proposed thresholds allergic sensitization and morbidity. Methods: A prerandomized, nonmasked trial with 16 15 control homes conducted. Study inclusion based on 50 500 cockroaches trapped 3-day period. interventions consisted occupant education, placement insecticide bait, professional cleaning. Vacuumed dust multiple swab samples were collected at 0, 1, 2, 4, 6 months 0 Room maps containing data used guide monitor interventions. Results: From among homes, geometric (U/g dust) decreased from 633 24 kitchen floors (96% reduction), 25 4.3 living room floors/sofas (83% 46 7.3 bedroom (84% 6.1 1.0 beds reduction). These reductions, exception that floor ( P = .06), statistically significant relative changes Conclusions: Substantial levels can be achieved In this study, reduced threshold (2 U/g) beds, arguably most site exposure, morbidity (8 floors/sofas. level floors, although 96%, remained above threshold. Future studies will test intervention's effectiveness prevention (J Allergy Clin Immunol 2003;112:339-45.)