Insulin-like factor 3: a novel circulating hormone of testicular origin in humans.
作者： ALBERTO FERLIN , CARLO FORESTA
关键词:
摘要: Insulin-like factor 3 (INSL3) affects testicular descent. Mutations in the INSL3 gene or its receptor, LGR8/GREAT, can cause cryptorchidism. Expression of LGR8/GREAT different tissues and production by adult-type Leydig cells suggest additional roles for this hormonal system adults. We used a novel radioimmunoassay kit to measure concentrations serum normal men those with pathologies. demonstrate that circulates adult is almost exclusively origin. Subjects severe damage (infertility) produce small amounts INSL3, hormone seem reflect functional status cells. Analysis treated combinations hormones hypothalamus-pituitary-testis axis suggests related luteinizing hormone.
core.ac.uk
harvard.edu
sci-hub.se 参考文章(28)
Carlo Foresta, Alberto Varotto, Cesare Scandellari, Assessment of testicular cytology by fine needle aspiration as a diagnostic parameter in the evaluation of the oligospermic subject Fertility and Sterility. ,vol. 57, pp. 858- 865 ,(1992) , 10.1016/S0015-0282(16)54971-1
Serge Nef, Luis F. Parada, Cryptorchidism in mice mutant for Insl3. Nature Genetics. ,vol. 22, pp. 295- 299 ,(1999) , 10.1038/10364
Setsuko Sahara, Mamoru Aoto, Yutaka Eguchi, Naoko Imamoto, Yoshihiro Yoneda, Yoshihide Tsujimoto, Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation Nature. ,vol. 401, pp. 168- 173 ,(1999) , 10.1038/43678
Sylvie Franckhauser-Vogel, Martine Glorian, Claude Forest, Glucocorticoids use a positive liver element to repress fibrate-induced adipose transcription of the phosphoenolpyruvate carboxykinase gene Molecular and Cellular Endocrinology. ,vol. 127, pp. 171- 177 ,(1997) , 10.1016/S0303-7207(96)04006-3
Michael T. Nguyen, Patrick R. Showalter, Charles F. Timmons, Serge Nef, Luis F. Parada, Linda A. Baker, Effects of Orchiopexy on Congenitally Cryptorchid Insulin-3 Knockout Mice The Journal of Urology. ,vol. 168, pp. 1779- 1783 ,(2002) , 10.1016/S0022-5347(05)64412-6
Paul A. Overbeek, Ivan P. Gorlov, Richard W. Sutherland, John B. Houston, Wilbur R. Harrison, Holly L. Boettger-Tong, Colin E. Bishop, Alexander I. Agoulnik, A transgenic insertion causing cryptorchidism in mice. Genesis. ,vol. 30, pp. 26- 35 ,(2001) , 10.1002/GENE.1029
P. Canto, I. Escudero, D. Söderlund, E. Nishimura, S. Carranza-Lira, J. Gutierrez, A. Nava, J. P. Mendez, A novel mutation of the insulin-like 3 gene in patients with cryptorchidism. Journal of Human Genetics. ,vol. 48, pp. 86- 90 ,(2003) , 10.1007/S100380300012
Paola Marin, Alberto Ferlin, Enrico Moro, Alessandra Rossi, Lucia Bartoloni, Marco Rossato, Carlo Foresta, Novel insulin‐like 3 (INSL3) gene mutation associated with human cryptorchidism American Journal of Medical Genetics. ,vol. 103, pp. 348- 349 ,(2001) , 10.1002/AJMG.1579
Alberto Ferlin, Mauro Simonato, Lucia Bartoloni, Giorgia Rizzo, Andrea Bettella, Tania Dottorini, Bruno Dallapiccola, Carlo Foresta, The INSL3-LGR8/GREAT ligand-receptor pair in human cryptorchidism. The Journal of Clinical Endocrinology and Metabolism. ,vol. 88, pp. 4273- 4279 ,(2003) , 10.1210/JC.2003-030359
B. M. CATTANACH, CAROL A. IDDON, H. M. CHARLTON, SHARON A. CHIAPPA, G. FINK, Gonadotrophin-releasing hormone deficiency in a mutant mouse with hypogonadism Nature. ,vol. 269, pp. 338- 340 ,(1977) , 10.1038/269338A0