On hyperglicemic glucose basal levels in Type 1 Diabetes Mellitus from dynamic analysis.

摘要: Compartmental-Physiological Models (CPM's) have been used to derive feedback controllers for the glucose regulation in Diabetes Mellitus (DM). Despite these important advances, there are two criticisms about use of CPM's DM: (i) Can this class model reproduce severe basal levels (e.g., larger than 300 mg/dl)? and (ii) Does a CPM distinct level as its parameters change or is it unique even if change? This contribution aims from study parametric sensitivity CPM. The results exploit analysis dynamic properties chosen permit show that such can by modifying values metabolic parameters, which agree with expectations on realistic model. Mainly, has selected due following reasons. It includes main organs related metabolism Type 1 (T1DM); as, example, liver, brain kidney. models phenomena instance, counter-regulatory effects glucagon hepatic uptake/production. Additionally, recently design very promissory results.