Turning on ARF: the Sec7 family of guanine-nucleotide-exchange factors

作者: Catherine L. Jackson , James E. Casanova

DOI: 10.1016/S0962-8924(99)01699-2

关键词:

摘要: ARF proteins are important regulators of membrane dynamics and protein transport within the eukaryotic cell. The Sec7 domain is approximately 200 amino acids in size stimulates guanine-nucleotide exchange on members class small GTPases. one subclass Sec7-domain direct targets secretion-inhibiting drug brefeldin A, which blocks reaction by trapping a intermediate an inactive, abortive complex. A separate involved signal transduction possess that mediates binding response to extracellular signals.

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