Modulations in the biotransformation of tobacco extract and N'-nitrosonornicotine under differential dietary protein status.

作者: N. Ammigan , U. J. Nair , A. J. Amonkar , S. V. Bhide

DOI: 10.1002/JBT.2570040103

关键词:

摘要: The modulation of the phase I and II biotransformation enzymes upon treatment with tobacco extract (TE) N'-nitrosonornicotine (NNN) was investigated using male Sprague-Dawley rats fed differential protein diets. It observed that animals a low diet showed an overall decrease in basal levels hepatic pulmonary enzymes. TE NNN significantly decreased detoxifying system low-protein-fed animals. Animals 20% protein, however, significant increases glutathione S-transferase treatment. Furthermore, brought about depletion pool vitamin A concomitant increase C levels.

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