De novo lipogenesis is suppressed during fasting but upregulated at population decline in cyclic voles
作者： Petteri Nieminen , Kirsti Rouvinen-Watt , Lora Harris , Otso Huitu , Heikki Henttonen
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摘要: Arvicolines are susceptible to the development of fatty liver during short-term fasting. We examined potential role de novo lipogenesis (DNL) (i) in fasting-induced and (ii) a population cycle by measuring mRNA expression acetyl-CoA carboxylase-1 (ACC1) acid synthase (FAS). Laboratory voles (Microtus oeconomus Microtus arvalis) were fed or fasted for 12 18 h their levels determined. Both species showed decreased ACC1 FAS This suggests that DNL does not participate voles, different from human non-alcoholic disease. In wild bank (Myodes glareolus), genes interest higher decline compared increase phase. conclusion, was suppressed acute fasting but upregulated long-term decline—a period purported scarcity high-quality food.
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Petteri Nieminen, Otso Huitu, Heikki Henttonen, Mikko A.J. Finnilä, Liina Voutilainen, Juhani Itämies, Vesa Kärjä, Seppo Saarela, Toivo Halonen, Jari Aho, Anne-Mari Mustonen, Physiological condition of bank voles (Myodes glareolus) during the increase and decline phases of the population cycle. Comparative Biochemistry and Physiology A-molecular & Integrative Physiology. ,vol. 187, pp. 141- 149 ,(2015) , 10.1016/J.CBPA.2015.05.007
Jean Girard, Dominique Perdereau, Fabienne Foufelle, Carina Prip‐Buus, Pascal Ferré, Regulation of lipogenic enzyme gene expression by nutrients and hormones. The FASEB Journal. ,vol. 8, pp. 36- 42 ,(1994) , 10.1096/FASEBJ.8.1.7905448
Cynthia A. Nagle, Eric L. Klett, Rosalind A. Coleman, Hepatic triacylglycerol accumulation and insulin resistance Journal of Lipid Research. ,vol. 50, ,(2009) , 10.1194/JLR.R800053-JLR200
A G Dulloo, M Gubler, J P Montani, J Seydoux, G Solinas, Substrate cycling between de novo lipogenesis and lipid oxidation: a thermogenic mechanism against skeletal muscle lipotoxicity and glucolipotoxicity. International Journal of Obesity. ,vol. 28, ,(2004) , 10.1038/SJ.IJO.0802861
Concepcion Gonzalez, Victor de Ledinghen, Julien Vergniol, Juliette Foucher, Brigitte Le Bail, Sabrina Carlier, Elisa Maury, Henri Gin, Vincent Rigalleau, Hepatic Steatosis, Carbohydrate Intake, and Food Quotient in Patients with NAFLD International Journal of Endocrinology. ,vol. 2013, pp. 428542- 428542 ,(2013) , 10.1155/2013/428542
Kerry L. Donnelly, Coleman I. Smith, Sarah J. Schwarzenberg, Jose Jessurun, Mark D. Boldt, Elizabeth J. Parks, Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease Journal of Clinical Investigation. ,vol. 115, pp. 1343- 1351 ,(2005) , 10.1172/JCI23621
Anne-Mari Mustonen, Reijo Käkelä, Toivo Halonen, Vesa Kärjä, Eero Vartiainen, Petteri Nieminen, Fatty acid mobilization in voles--model species for rapid fasting response and fatty liver. Comparative Biochemistry and Physiology A-molecular & Integrative Physiology. ,vol. 163, pp. 152- 160 ,(2012) , 10.1016/J.CBPA.2012.05.196
Antonin Lamaziere, Claude Wolf, Ullah Barbe, Pedro Bausero, Francesco Visioli, Lipidomics of hepatic lipogenesis inhibition by omega 3 fatty acids Prostaglandins, Leukotrienes and Essential Fatty Acids. ,vol. 88, pp. 149- 154 ,(2013) , 10.1016/J.PLEFA.2012.12.001
A.F. Mosin, Some physiological and biochemical features of starvation and refeeding in small wild rodents (Microtinae) Comparative Biochemistry and Physiology Part A: Physiology. ,vol. 71, pp. 461- 464 ,(1982) , 10.1016/0300-9629(82)90435-2
Tobias Maier, Marc Güell, Luis Serrano, Correlation of mRNA and protein in complex biological samples FEBS Letters. ,vol. 583, pp. 3966- 3973 ,(2009) , 10.1016/J.FEBSLET.2009.10.036