Biocompatible and biodegradable alginate/poly(N‐isopropylacrylamide) hydrogels for sustained theophylline release

摘要: Mixed-interpenetrated polymeric networks based on sodium alginate (ALG) and poly(N-isopropylacryl amide) (PNI- PAAm) covalently cross-linked with N,N'-methylenebisacrylamide are studied for their biocompatibility, nontoxicity, biodegrad- ability aiming application in drug delivery. The presence of drug-polymeric matrix interactions the distribution network theophylline-loaded ALG/PNIPAAm hydrogels also investigated by spectroscopic microscopic methods. quantitative evaluation theophylline loaded performed NIR-CI technique shows a better entrap- ment higher homogeneity samples increased content. thermal behavior is significantly modified presence. as carriers sustained release formula- tions was assessed tests both vitro vivo studies. V C 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40733.