Dynamic molecular imaging of cardiac innervation using a dual headpinhole SPECT system

摘要: Typically 123I-MIBG is used for the study of innervation and function sympathetic nervous system in heart failure. The protocol involves two studies: first a planar or SPECT scan performed to measure initial uptake tracer, followed some 3-4 hours later by another measuring wash-out tracer from heart. A fast indicative compromised In this work, dual head pinhole was imaging distribution kinetics myocardium spontaneous hypertensive rats (SHR) normotensive Wistar Kyoto (WKY) rats. geometry calibrated based on nonlinear point projection fitting method using three-point source phantom. angle variation effect parameters modeled with sinusoidal function. dynamic acquisition injecting into immediately after starting data acquisition. detectors rotated continuously performing 360o every 90 seconds. We applied factor analysis (FA)method region interest (ROI) sampling obtain time activity curves (TACs)in blood pool then two-compartment modeling estimate kinetic parameters. Since injection bolus too obtaining consistent tomographic set few minutes study, we FA directly projections during rotation. Then active myocardial tissue were obtained ROI sampling. determine if there differences between SHR WKY requires less replacing delayed at over 120 minutes. results faster washout smaller volume 123IMIBG near end life model hypertrophic cardiomyopthy may be failing late stages