Genetic influences on central abdominal fat: a twin study.

摘要: INTRODUCTION : Recent studies of regional fat distribution have focused on the clinical importance central abdominal obesity. Central adiposity is strongly related to insulin resistance, non-insulin dependent diabetes mellitus (NIDDM), dyslipidaemia and cardiovascular disease. While significant genetic influences body mass index (BMI), total subcutaneous been demonstrated, inheritance obesity, has not studied. OBJECTIVE To assess effects associated metabolic parameters. DESIGN AND SUBJECTS We directly measured body, (C-abd) non-abdominal using dual energy X-ray absorptiometry in 50 monozygotic (MZ) 36 dizygotic (DZ) female twins, age (mean ± SD), 44 12 47 14 y ; BMI 24 5 3 kg/m 2 C-abd 33 9 32 9%, respectively. Total variance all parameters was independent zygosity analyses were performed before after adjusting for percentage fat. RESULTS A influence observed population fat, (C-abd rMZ = 0.66 vs rDZ 0.20, p 0.03) non After there a accounting approximately 70% (rMZ 0.61 0.40, 0.001). CONCLUSION The majority inter-subject non-obese individuals due factors. with its consequences, may contribute familial aggregation