Mesoporous carbon/CuS nanocomposites for pH-dependent drug delivery and near-infrared chemo-photothermal therapy
作者： Lei Zhang , Yecheng Li , Zexun Jin , King Ming Chan , Jimmy C. Yu
DOI: 10.1039/C5RA19458J
关键词:
摘要: Spurred by the recent development in nanotechnology, multi-functional therapeutic platforms have emerged as promising anti-cancer treatments for their combinational effects. In this paper, we report a novel drug delivery system composed of mesoporous carbon nanospheres (MCN) 150 to 200 nm diameter capped with copper sulfide (CuS) nanoparticles (NPs). MCNs can efficiently load doxorubicin (DOX, an drug) due hollow and porous structures well π–π stacking interactions between MCN DOX. DOX is retained under basic physiological environment, but releases rapidly acidic environment its ionized state. Due intrinsic near-infrared (NIR) absorption photothermal conversion ability nanoparticles, heat generated killing tumor cells stimulating release upon NIR irradiation. Thus, complex (MCN–CuS) exhibits efficient loading, low pre-release, temperature-, NIR- pH-responsive release, combined antitumor activity.
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