Retroperitoneal nodal metastasis in primary and recurrent granulosa cell tumors of the ovary

摘要: Abstract Objective. To describe the incidence of retroperitoneal pelvic or paraaortic lymph node metastasis in patients with primary and recurrent ovarian granulosa cell tumors. Methods. At Memorial Sloan-Kettering Cancer Center, we conducted a retrospective chart review all tumors managed as inpatients from January 1991 to July 2005. The initial date diagnosis ranged 1971 Results. We identified 68 median age 49 years (mean, 47.5 years; range, 19–78 years). Sixty-four (94%) had adult type 4 (6%) juvenile Fifty-three (78%) their surgery at another institution 55 (81%) were incompletely surgically staged due absence and/or aortic dissection. Patients assigned an International Federation Gynecology Obstetrics (FIGO) stage that included IA, 39; IC, 15; IIB, 3; IIC, IIIC, 1. In 7 patients, original was not assigned. Only 16 (24%) sampling 13 (19%) also restaging performed shortly following diagnosis; however, these cases, nodes negative for metastasis. number removed 10 11.6 nodes; 0–36 nodes). 6 0–19 Nine 15 (60%) initially our compared 53 (7.5%) who elsewhere ( P Thirty-four during study, 31 (91%) tumor, 3 histology. Thirty-three 34 recurred operation. Original "clinical" FIGO 8; 1; available. disease-free interval first recurrence 63 months (mean,69.4 months; 4–170 months). First sites pelvis, 24/34 (70%); pelvis abdomen, (9%); retroperitoneum only, 2 (6%); retroperitoneum, pelvis/abdomen/retroperitoneum, 1(3%); abdomen 1 (3%); bone, (3%). Conclusions. Complete surgical staging approximately 1/5 women tumors; those staged, no nodal identified. Clinical IA disease most common recurred, 15% recurrences appear involve retroperitoneum.