A role for TrkA nerve growth factor receptors in mammalian ovulation

摘要: Several members of the neurotrophin (NT) family, including nerve growth factor (NGF), NT-3, and NT-4/5, are expressed in mammalian ovary. As their respective receptor tyrosine kinases also found gland, possibility exists that NTs act directly on gonads to exert effects unrelated support ovarian innervation. We now report trkA, NGF kinase, is involved acute activational process leads first ovulation. The trkA gene becomes transiently periovulatory follicules at time preovulatory surge gonadotropins puberty; increase messenger RNA (mRNA) content dramatic ( > 100-fold), but transient (approximately 9 h). No such changes trkB or trkC mRNA were observed; abundance these mRNAs, which encode kinase for NT-4/5 brain-derived neurotrophic factor, respectively, remained very low levels throughout puberty. In vivo vitro experime...