Assessing the Stability of Alzheimer’s Amyloid Protofibrils Using Molecular Dynamics

摘要: Amyloid fibrils represent a stable form of many misfolded proteins associated with numerous diseases. Among these are Parkinson’s disease (α-synuclein), Type II diabetes (islet amyloid polypeptide), and Alzheimer’s (amyloid β-peptide, Aβ). The appearance Aβ in neural tissue is hallmark disease, studies have been conducted to determine analyze the structure protein aggregates. principal toxic species believed be soluble, oligomeric aggregates Aβ, but found that insoluble fibrillated peptide also contributes neurotoxicity. Thus, design therapeutic agents combat progression it worthwhile understand thermodynamics destabilizing features contribute their stability. In this work, we present systematic study several factors influence stability Aβ42 following silico mutatio...