High-dose methylprednisolone prevents extensive sick leave after whiplash injury : A prospective, randomized, double-blind study

摘要: STUDY DESIGN: A prospective, randomized, double-blind study comparing high-dose methylprednisolone with placebo. OBJECTIVES: To evaluate the efficacy of when administered within 8 hours after whiplash injury. SUMMARY OF BACKGROUND DATA: Whiplash injury often results in chronic symptoms. The management injuries is controversial, and pharmacologic therapy has received little evaluation. In recent reports, dysfunction central nervous system been indicated several cases. Methylprednisolone to patients acute spinal cord demonstrated improve outcome. This procedure was also adopted a randomized cases car accidents. METHODS: Forty patients, 22 men 18 women mean age 35 years (range, 19-65), were included study, 20 each two groups. They treated for injury, which they had sustained enrolled if their diagnoses complete treatment begun Disabling symptoms severe enough prevent patient from returning work, number sick days before sick-leave profile used as parameters evaluation effects treatment. Baseline demographic data controlled statistical analysis performed. RESULTS: At follow-up examination 6 months initial treatment, there significant difference disabling between actively placebo group (P = 0.047), total 0.01), 0.003). CONCLUSIONS: this indicate that may be beneficial preventing extensive leave However, studied small, therefore further studies are needed. Language: en