Effects of telmisartan and olmesartan on insulin sensitivity and renal function in spontaneously hypertensive rats fed a high fat diet.

摘要: Although telmisartan, an angiotensin II receptor blocker (ARB), has agonistic action for proliferator-activated (PPAR)-γ in vitro, it remains to be determined whether telmisartan exerts such vivo using a non-toxic dose (<5 mg/kg rats). To address the issue, (2 mg/kg) and olmesartan mg/kg), another ARB without PPAR-γ action, were given spontaneously hypertensive rats (SHR) fed high fat diet (HFD). HFD decreased plasma adiponectin, caused insulin resistance, hypertriglyceridemia renal damage, which improved by ARBs. Protective effects of did not significantly differ. In addition, vitro study showed that 1 μM elevate mRNA expression adipose protein 2, is PPAR-γ-stimulated adipogenic marker gene, preadipocytes with 3% albumin. obtain concentration, oral was calculated 6 mg/kg, indicates negligible rats. This 2 ameliorated damage SHR HFD. As beneficial differ, these mediated through PPAR-γ-independent actions.