On-line concentration and determination of all-trans- and 13-cis- retinoic acids in rabbit serum by application of sweeping technique in micellar electrokinetic chromatography.
作者： Bo Wang , Yayan Wu , Hong Wu , Yongxi Zhao , Yu Kong
DOI: 10.1016/J.CHROMA.2007.02.022
关键词:
摘要: Abstract A simple and rapid micellar electrokinetic chromatography (MEKC) method with UV detection was developed for the simultaneous separation determination of all- trans - 13- cis -retinoic acids in rabbit serum by on-line sweeping concentration technique. The sample simply deproteinized centrifuged. Various parameters affecting enrichment were systematically investigated. Under optimal conditions, analytes could be well separated within 17 min, relative standard deviations (RSD) migration times peak areas less than 3.4%. Compared conventional MEKC injection method, 18- 19-fold improvements sensitivity achieved, respectively. proposed has been successfully applied to samples from rabbits feasible further pharmacokinetics study acid.
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