Are nanostructured lipid carriers (NLCs) better than solid lipid nanoparticles (SLNs): Development, characterizations and comparative evaluations of clotrimazole-loaded SLNs and NLCs?
作者： Surajit Das , Wai Kiong Ng , Reginald B.H. Tan
DOI: 10.1016/J.EJPS.2012.05.010
关键词:
摘要: In recent years, solid lipid nanoparticles (SLNs) and nanostructured carriers (NLCs) are among the popular research topics for delivery of lipophilic drugs. Although SLNs have demonstrated several beneficial properties as drug-carrier, limited drug-loading expulsion drug during storage led to development NLCs. However, superiority NLCs over has not been fully established yet due contradictory results. this study, were developed using clotrimazole model drug. Size, polydispersity index (PI), zeta potential (ZP), (L), encapsulation efficiency (EE), scanning electron microscopy (SEM), differential calorimetry (DSC), X-ray diffractometry (XRD), release stability compared. Critical process parameters exhibited significant impact on nanoparticles' properties. PI, ZP EE 82%, respectively. SEM images revealed spherical shaped particles (≈ 100 nm). DSC XRD studies indicated slight difference between well disappearance crystalline peak(s) encapsulated faster than at low drug-loading, whereas there was no in from high drug-loading. sustained/prolonged observed both formulations. Furthermore, study suggests that experiment should be designed considering final application (topical/oral/parenteral) product. Regarding stability, showed better (in terms size, L) 25°C. Moreover, profile after 3 months compare fresh NLCs, while change rate case SLNs. Therefore, an edge
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