Dopamine neurotransmission and atypical antipsychotics in prefrontal cortex: a critical review.

摘要: Schizophrenia has been historically characterized by the presence of positive symptomatology, however, decades research highlight importance cognitive deficits in this disorder. At present, impairments remain one most important unmet therapeutic needs schizophrenia. The prefrontal cortex (PFC) controls a large number higher brain functions altered variety psychiatric disorders, including Histological studies indicate proportion PFC neurons expressing monoaminergic receptors sensitive to action current atypical antipsychotics. Functional also show that these medications act at level increase dopamine neurotransmission mesocortical pathway. Here we focus on molecular targets are actively being explored as potential agents basic and clinical neuroscience research, support development co-treatments used conjunction with antipsychotic medications. These include serotonin cortex, well elements noradrenergic system.