Poisoning with Over-the-Counter Doxylamine Preparations: An Evaluation of 109 Cases:

摘要: One hundred and nine cases of monointoxication with doxylamine were evaluated respect to age distribution, amount ingested, plasma level, clinical symptomatology. The 60% the patients ranged between 16 30 years. In about 10 40 times a single therapeutic dose (25 mg) was ingested. Doxylamine concentrations exceeded maximum level after by factor in two-thirds cases. most frequent symptoms included impaired consciousness, seizures, tachycardia, mydriasis 'psychosis' similar that catatonic stupor. A serious complication may be rhabdomyolysis subsequent impairment renal function acute failure. No observed 39% patients. correlation found ingested or Primary detoxication gastric lavage, administration activated charcoal sodium sulfate. Regarding high frequenc...