Perfluorooctane sulfonate and perfluorooctanoic acid

摘要: Abstract Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) are fluorinated hydrocarbons used as water-, oil-, stain-resistant coatings in fabrics, leather, carpets, oil-resistant for paper products food contact, also photographic emulsifier, aviation hydraulic fluids, fire-fighting foams. They not reactive easily degraded, making them persistent present the environment humans, where they can be transferred from mother to offspring during gestation lactation. PFOS PFOA induce reproductive developmental toxic effects different species organs. The most studied mechanisms of action peroxisome proliferator-activator receptors, thyroid hormone system, fatty homeostasis, cell communication. In such changed birth variables, delayed development, decreased fecundity both men women. Animal studies have revealed that exposure PFOA, gestational and/or neonatal period, induces mainly on developing lungs nervous changes important proteins, impaired behavior, learning, memory adult individual. These findings led regulation Europe United States these compounds been proposed considered organic pollutants Nations other international environmental conventions. Even so, more toxicological research is needed, especially concerning interactions with pollutants, gain better knowledge about perform high-quality risk assessments legislation.