METHODS FOR PREPARING DNA REFERENCE MATERIALS AND CONTROLS

摘要: Disclosed are controls and reference materials for use in identifying any of a number genotypes and/or or characterizing disease condition. The may be particularly useful diagnostic tests that utilize circulating cell-free DNA (cfDNA). Also disclosed herein methods generating large quantities cfDNA preserve the original size input sequences. In some embodiments, comprise amplifying, digesting, purifying isolated from subject. tumor ("ctDNA). result ctDNA clone library is significantly more "commutable" compared to existing methods.