Juxtaposed regions of extensive and minimal linkage disequilibrium in human Xq25 and Xq28.

摘要: Linkage disequilibrium (LD), or the non-random association of alleles, is poorly understood in human genome1. Population genetic theory suggests that LD determined by age markers, population history, recombination rate, selection and drift2. Despite uncertainties determining relative contributions these factors, some groups have argued a simple function distance between markers3,4. Disease-gene mapping studies simulation study gave differing predictions on degree isolated general populations5,6. In view discrepancies experimental observations, we constructed high-density SNP map Xq25–Xq28 region7 analysed male genotypes haplotypes across this region for three populations. The populations included an outbred European sample (CEPH males) samples from Finland Sardinia. We found two extended regions strong bracketed with no evidence all samples. Haplotype analysis showed paucity LD. Our results suggest that, X chromosome, not monotonic but more property particular location genome.