Programmable patterns in a DNA-based reaction–diffusion system

摘要: Biology offers compelling proof that macroscopic "living materials" can emerge from reactions between diffusing biomolecules. Here, we show molecular self-organization could be a similarly powerful approach for engineering functional synthetic materials. We introduce programmable DNA embedded hydrogel produces tunable patterns at the centimeter length scale. generate these by implementing chemical reaction networks through complexes, embedding complexes in hydrogel, and triggering with locally applied input strands. first demonstrate ring pattern formation around circular cavity width intensity predictably tuned. Then, create of increasing complexity, including concentric rings non-isotropic patterns. Finally, "destructive" "constructive" interference patterns, combining several ring-forming modules gel them multiple sources. further computer simulations based on reaction-diffusion model predict inform programming target