Adverse impact of bleeding and transfusion on the outcome post-transcatheter aortic valve implantation: Insights from the Pooled-RotterdAm-Milano-Toulouse In Collaboration Plus (PRAGMATIC Plus) initiative

摘要: Background Little is known about the impact of bleeding and red blood cells transfusion (RBC) on outcome post transcatheter aortic valve implantation (TAVI). Methods Between November 2005 August 2011, 943 consecutive patients underwent TAVI. Bleeding was assessed according to Valve Academic Research Consortium definitions. Patients receiving RBC were compared those not requiring transfusion. Results Life-threatening major bleedings occurred respectively in 13.9% 20.9% patients, significantly more frequently cohort. Vascular complications 23.2% patients. Major minor vascular frequent group: 19.3 vs 5.2%, P = .003, respectively. Thirty-day all-cause mortality 7.2%. Of overall cohort, 38.9% required transfusion; at least 4 U had higher 30-day than 1 transfusion: 14.4%, 6.3% 6.3%, respectively, .008. By multivariate analysis, associated with an increased 1-year mortality. stroke all stages acute kidney injury Conclusions after TAVI, mainly driven by complications. year risk injury. Specific scores are needed identify for TAVI-related