Sequencing of disease-modifying therapies for relapsing–remitting multiple sclerosis: a theoretical approach to optimizing treatment

摘要: AbstractMultiple sclerosis (MS) is a chronic disease which usually begins in young adulthood and lifelong condition. Individuals with MS experience physical cognitive disability resulting from inflammation demyelination the central nervous system. Over past decade, several disease-modifying therapies (DMTs) have been approved for management of relapsing–remitting (RRMS), most prevalent phenotype. The nature multiple treatment options make benefit–risk-based sequencing therapy essential to ensure optimal care. efficacy short- long-term risks differ each DMT due their different mechanism action on immune While transitioning between DMTs, addition system effects, factors such as age, duration severity, status, monitoring requirements, preference route administration, family planning play an important role. Determining strategy ...