Static and dynamic light scattering of healthy and malaria-parasite blood cells
作者： Michael S. Feld , Ishan Barman , YongKeun Park , Gabriel Popescu , Monica Diez-Silva
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摘要: Abstract. We present the light scattering of individual Plasmodium falciparum -parasitized human red bloodcells Pf-RBCs , and demonstrate progressive alterations tothe signal arising from development ofmalaria-inducing parasites. By selectively imaging theelectric fields using quantitative phase microscopy aFourier transform technique, we calculatethe maps Pf-RBCs. showthat onset progression pathological states thePf-RBCs can be clearly identified by static scatteringmaps. Progressive changes to biophysical properties ofthe Pf-RBC membrane are captured dynamic lightscattering. © 2010 Society Photo-Optical Instrumentation Engineers. DOI: 10.1117/1.3369966 Keywords: blood cell; plasmodium ; scattering;malaria; electric field . Paper 09414LRR received Sep. 14, 2009; revised manuscript receivedFeb. 23, 2010; accepted for publication Feb. 26, publishedonline Apr. 5, 2010.
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