The TIGRFAMs database of protein families

摘要: TIGRFAMs is a collection of manually curated protein families consisting hidden Markov models (HMMs), multiple sequence alignments, commentary, Gene Ontology (GO) assignments, literature references and pointers to related TIGRFAMs, Pfam InterPro models. These are designed support both automated annotation genomes. contains full-length proteins shorter regions at the levels superfamilies, subfamilies equivalogs, where equivalogs sets homologous conserved with respect function since their last common ancestor. The scope each model set by raising or lowering cutoff scores choosing members seed alignment group sharing specific (equivalog) more general properties. overall goal provide information maximum utility for process. thus complementary Pfam, whose typically achieve broad coverage across distant homologs but end boundaries structural domains. database currently over 1600 families. available searching downloading www.tigr.org/TIGRFAMs.