The role of retinoic acid receptors in neurite outgrowth from different populations of embryonic mouse dorsal root ganglia.
作者： Jonathan Corcoran , Malcolm Maden , John Pizzey , B Shroot
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摘要: Dorsal root ganglion (DRG) neurons can be categorised into at least three types, based upon their neurotrophin requirement for survival. We have analysed the expression of retinoic acid receptors (RARs) and retinoid X (RXRs) in NGF, NT-3 BDNF dependent isolated from embryonic day (E)13.5 mouse DRG. show that each population expressed RXRs, (alpha), (beta) (gamma); however, whilst NGF RARs (gamma), only RAR(alpha) (beta). When was added to neuronal classes responded by extending neurites, this response involved upregulation RAR(beta)(2). This specificity confirmed use receptor-selective agonists as a RAR(beta)-selective compound stimulated neurite outgrowth. These results suggest role RA acting via RAR(beta)(2) outgrowth neurites.
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biologists.org参考文章(42)
M. Maden, Retinoids in Neural Development Handbook of experimental pharmacology. ,vol. 139, pp. 399- 442 ,(1999) , 10.1007/978-3-642-58483-1_14
P. Leroy, A. Krust, A. Zelent, C. Mendelsohn, J. M. Garnier, P. Kastner, A. Dierich, P. Chambon, Multiple isoforms of the mouse retinoic acid receptor alpha are generated by alternative splicing and differential induction by retinoic acid. The EMBO Journal. ,vol. 10, pp. 59- 69 ,(1991) , 10.1002/J.1460-2075.1991.TB07921.X
A. Zelent, C. Mendelsohn, P. Kastner, A. Krust, J. M. Garnier, F. Ruffenach, P. Leroy, P. Chambon, Differentially expressed isoforms of the mouse retinoic acid receptor beta generated by usage of two promoters and alternative splicing. The EMBO Journal. ,vol. 10, pp. 71- 81 ,(1991) , 10.1002/J.1460-2075.1991.TB07922.X
M. Leid, P. Kastner, P. Chambon, R. Blomhoff, Role of nuclear retinoic acid receptors in the regulation of gene expression. Vitamin A in health and disease.. pp. 189- 238 ,(1994)
Jonathan Corcoran, Malcolm Maden, Nerve growth factor acts via retinoic acid synthesis to stimulate neurite outgrowth. Nature Neuroscience. ,vol. 2, pp. 307- 308 ,(1999) , 10.1038/7214
R. Levi-Montalcini, The nerve growth factor: thirty-five years later. The EMBO Journal. ,vol. 6, pp. 1145- 1154 ,(1987) , 10.1002/J.1460-2075.1987.TB02347.X
Y.A. Barde, D. Edgar, H. Thoenen, Purification of a new neurotrophic factor from mammalian brain. The EMBO Journal. ,vol. 1, pp. 549- 553 ,(1982) , 10.1002/J.1460-2075.1982.TB01207.X
N. E. Sladek, P. Mccaffery, M. A. Wagner, U. C. Dräger, Mi-Ock Lee, Asymmetrical retinoic acid synthesis in the dorsoventral axis of the retina. Development. ,vol. 115, pp. 371- 382 ,(1992)
RM Lindsay, Nerve growth factors (NGF, BDNF) enhance axonal regeneration but are not required for survival of adult sensory neurons The Journal of Neuroscience. ,vol. 8, pp. 2394- 2405 ,(1988) , 10.1523/JNEUROSCI.08-07-02394.1988
Craig Crowley, Susan D. Spencer, Merry C. Nishimura, Karen S. Chen, Sharon Pitts-Meek, Mark P. Armaninl, Lanway H. Ling, Stephen B. McMahon, David L. Shelton, Arthur D. Levinson, Heidi S. Phillips, Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons. Cell. ,vol. 76, pp. 1001- 1011 ,(1994) , 10.1016/0092-8674(94)90378-6