Sulfation of the 3,4-methylenedioxymethamphetamine (MDMA) metabolites 3,4-dihydroxymethamphetamine (DHMA) and 4-hydroxy-3-methoxymethamphetamine (HMMA) and their capability to inhibit human sulfotransferases.
作者： Andrea E. Schwaninger , Markus R. Meyer , Josef Zapp , Hans H. Maurer
DOI: 10.1016/J.TOXLET.2011.01.026
关键词:
摘要: Abstract 3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy) is excreted in human urine mainly as conjugates of its metabolites 3,4-dihydroxymethamphetamine (DHMA) and 4-hydroxy-3-methoxymethamphetamine (HMMA). The glucuronidation kinetics HMMA showed high capacities, but also K m values, unlikely to be reached after recreational user's doses. Therefore, the aim present work was investigate sulfation DHMA by sulfotransferases (SULTs) pooled liver cytosol (pHLC). kinetic data deviation from typical Michaelis–Menten kinetics. overall efficiency for calculated 2–10 times higher than glucuronidation. As both MDMA substrate inhibition effects, their inhibitory potential towards reactions pHLC tested. following substrates were used: nitrophenol, dopamine, estradiol, dehydroepi androsten dione. Inhibition observed dopamine HMMA, not MDMA. 1/ V vs. S plots indicated a mixed-type or competitive model respectively. In conclusion, presented that should major conjugation reaction humans. Furthermore, both, identified inhibitors sulfation.
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