Potential prevention of thromboembolism by genetic counseling and testing for two common thrombophilia mutations.

摘要: Background/Aim: Thrombophilia is a multifactorial predisposition for thromboembolism affecting about tenth of any population. We investigated whether genetic counseling combined with molecular testing two common dominant mutations (coagulation factor V Leiden and prothrombin G20210A) may increase prevention venous thromboembolic incidents in individuals positive family history compared to the general Patients Methods: Mutation detection was carried out by Restriction Fragment Length Polymorphism analysis DNA samples 96 unrelated healthy Greeks (group A) who asked various reasons had at least relatives 100 B). Results: In group A, both were detected five-fold higher frequencies (33.33% 19.79% B, which typically found Greek population (6% 4%, respectively). Conclusion: populations high prevalence these mutations, at-risk significantly disease.