Ordering Molecular Genetic Tests and Reporting Results: Practices in Laboratory and Clinical Settings

摘要: Previous studies have suggested that patient care may be compromised as a consequence of poor communication between clinicians and laboratory professionals in cases which molecular genetic test results are reported. To understand better the contributing factors to such care, we investigated both pre- postanalytical processes using cystic fibrosis mutation analysis our model. We found although majority requisition forms requested patient/family information was necessary for proper interpretation results, many cases, these data were not provided by individuals filling out forms. instances result reports simulated diagnostic testing described carriers where only single with no comment pertaining diagnosis fibrosis. Similarly, based on scenarios carrier problematic when mutations identified, patient's race/ethnicity family history discussed reference residual risk disease. Remarkably, pilot survey obstetrician-gynecologists revealed office staff, including secretaries, often helped order tests reported patients, raising questions about what efforts undertaken ensure personnel competency. These findings reviewed light should taken improve quality test-ordering result-reporting practices.