1,8-Naphthalimide hydroperoxides as novel intercalating DNA cleavers
作者： Zhi-Fu Tao , Xuhong Qian , Dongzhi Wei
DOI: 10.1016/0143-7208(95)00105-0
关键词:
摘要: Two new naphthalimide hydroperoxides 3 and 4 have been synthesized their interactions with DNA investigated. They efficiently intercalate into (in the dark) cleave (under irradiation, 365 nm) pBR322 pUC19 DNA. Their DNA-cleaving activities depend on incubation time temperature in dark, concentration of drugs, types buffers. In contrast, cleavage by 1, a phthalimide peroxide that has reported to act as cleaver, was not visible under same condition.
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