Insights on the human microbiome and its xenobiotic metabolism: what is known about its effects on human physiology?

摘要: Introduction: Our microbiome harbours a metabolic capacity far beyond our own. Moreover, its gene pool is highly adaptable and subject to selective pressure, including host exposure xenobiotics. Yet, the resulting adaptations do not necessarily follow well-being can therefore contribute disease or unfavourable metabolite production.Areas covered: This review provides an overview of host–microbiome relationship in light bacterial (xenobiotic) metabolism, community dynamics, entero-endocrine crosstalk, dysbiosis potential therapeutic targets. In addition, it will highlight need for systematic analysis microbiome’s substance toxification.Expert opinion: The influence microbiota reaches from primary metabolites secondary effects such as substrate competition activation eukaryotic Phase I II enzymes. Further on plays hitherto underestimated role drug toxicity pathogenesis. These are partly caused ...