A caffeic acid phenethyl ester analog inhibits the proliferation of nasopharyngeal carcinoma cells via targeting epidermal growth factor receptor

摘要: A previous study reported that compound 5A, a caffeic acid phenethyl ester (CAPE) analog, exhibited obvious neuroprotective activity, in particular, 5A possessed higher stability and membrane permeability than CAPE. CAPE displays antitumour function; therefore, evaluating the effect of its analog with is worthwhile. We first investigated activity 5A. found significantly inhibited proliferation tumor cells showed low cytotoxicity normal cells. Furthermore, was to induce cell cycle arrest apoptosis CNE2 Through prediction SwissTargetPrediction subsequent confirmation, epidermal growth factor receptor (EGFR) identified as target Compound also influenced expression genes downstream EGFR nasopharyngeal carcinoma (NPC) Based on these findings, inhibits NPC by targeting may become new candidate for treatment.