Ratio of trastuzumab levels in serum and cerebrospinal fluid is altered in HER2-positive breast cancer patients with brain metastases and impairment of blood-brain barrier.
作者： Hans-Joachim Stemmler , Manfred Schmitt , Amina Willems , Helga Bernhard , Nadia Harbeck
DOI: 10.1097/01.CAD.0000236313.50833.EE
关键词:
摘要: Patients receiving trastuzumab for HER2-overexpressing metastatic breast cancer seem to suffer from an increased risk of brain metastases, even in cases with responsive disease. To evaluate whether is able penetrate the blood–brain barrier, we measured levels serum
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