TauT gene expression is regulated by TonEBP and plays a role in cell survival.

作者: Takashi Ito , Yasushi Fujio , Yoriko Uozumi , Takahisa Matsuda , Makiko Maeda

DOI: 10.1007/978-0-387-33504-9_9

关键词:

摘要: In summary, this study shows that TonEBP regulates TauT expression in response to hypertonicity, and the TonEBP/TauT pathway plays an important role cytoprotection from hypertonic stress. The activation of could contribute protective signal against hypertonicity-related tissue damage.

参考文章(31)
S. W. Schaffer, V. Pastukh, V. Solodushko, J. Kramer, J. Azuma, Effect of ischemia, calcium depletion and repletion, acidosis and hypoxia on cellular taurine content. Amino Acids. ,vol. 23, pp. 395- 400 ,(2002) , 10.1007/S00726-002-0201-3
D. Häussinger, F. Schliess, U. Warskulat, S. vom Dahl, Liver cell hydration. Cell Biology and Toxicology. ,vol. 13, pp. 275- 287 ,(1997) , 10.1023/A:1007483324138
Xiaobin Han, Andrea M. Budreau, Russell W. Chesney, Cloning and characterization of the promoter region of the rat taurine transporter (TauT) gene. Advances in Experimental Medicine and Biology. ,vol. 483, pp. 97- 108 ,(2002) , 10.1007/0-306-46838-7_9
Ulrich WARSKULAT, Matthias WETTSTEIN, Dieter HÄUSSINGER, Osmoregulated taurine transport in H4IIE hepatoma cells and perfused rat liver Biochemical Journal. ,vol. 321, pp. 683- 690 ,(1997) , 10.1042/BJ3210683
Xiaobin Han, Russell W Chesney, Regulation of taurine transporter gene (TauT) by WT1. FEBS Letters. ,vol. 540, pp. 71- 76 ,(2003) , 10.1016/S0014-5793(03)00227-8
Anna Kordelia Kurz, Freimut Schliess, Dieter Häussinger, Osmotic regulation of the heat shock response in primary rat hepatocytes Hepatology. ,vol. 28, pp. 774- 781 ,(1998) , 10.1002/HEP.510280326
Steffan N Ho, The role of NFAT5/TonEBP in establishing an optimal intracellular environment. Archives of Biochemistry and Biophysics. ,vol. 413, pp. 151- 157 ,(2003) , 10.1016/S0003-9861(03)00130-9
Hiroyasu Satoh, Nicholas Sperelakis, Review of some actions of taurine on ion channels of cardiac muscle cells and others General Pharmacology-the Vascular System. ,vol. 30, pp. 451- 463 ,(1998) , 10.1016/S0306-3623(97)00309-1
Xiaobin Han, Andrea Budreau Patters, Russell W. Chesney, Transcriptional Repression of Taurine Transporter Gene (TauT) by p53 in Renal Cells Journal of Biological Chemistry. ,vol. 277, pp. 39266- 39273 ,(2002) , 10.1074/JBC.M205939200