Interplay between inflammation and tumor angiogenesis

摘要: The association of inflammation and neoplasia was first observed when Westphal reported dense areas mast cells at the periphery tumors in 1891 [1]. These inflammatory infiltrating tumor tissues were believed to mediate phagocytic functions aid host defense against tumor. Now a new paradigm is being widely accepted that site may actually facilitate progression instead promoting anti-tumor immunity. diverse contributions tumor-infiltrating neoplastic include epithelial cell proliferation, rendering angiogenic potential, enabling invasiveness [2]. most direct evidence supporting role disease comes from epidemiological studies cancer risk among long-term users aspirin non-steroidal anti-inflammatory drugs (NSAIDs). Significant reduction developing colon, lung, esophagus, stomach cancers these [3, 4].