Acute and subchronic effects on immune responses of carp (Cyprinus carpio L.) after exposure to deoxynivalenol (DON) in feed
作者： Constanze Pietsch , Barbara A. Katzenback , Erick Garcia-Garcia , Carsten Schulz , Miodrag Belosevic
DOI: 10.1007/S12550-015-0226-6
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摘要: The mycotoxin deoxynivalenol (DON) has been shown to regularly occur at relevant concentrations in feed designed for aquaculture use, but little is known about the consequences of its presence on organisms that consume DON-contaminated feed. Previous studies indicated a down-regulation pro-inflammatory responses carp (Cyprinus carpio L.) after 4 weeks feeding DON. present study examined time course innate immune orally administered Changes mRNA levels genes different organs (head kidney, trunk spleen, liver, and intestine) were observed indicating immune-modulating properties immune-modulatory effects during acute phase DON exposure characterized by activation both pro- anti-inflammatory cytokines enzymes carp. subchronic arginases culminating increased arginase activity head kidney leukocytes 26 days treatment. These results suggest profound this fish aquaculture.
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James R. Bamburg, Biological and Biochemical Actions of Trichothecene Mycotoxins Progress in molecular and subcellular biology. pp. 41- 110 ,(1983) , 10.1007/978-3-642-69228-4_3
E. Ferrer, J. Tolosa, G. Font, J. Mañes, Natural occurrence of Fusarium mycotoxins in aquaculture fish food Revista de Toxicología. ,vol. 30, pp. 193- 197 ,(2013)
Fred E. Hahn, Progress in Molecular and Subcellular Biology ,(2011)
Christian Bogdan, Nitric oxide and the immune response Nature Immunology. ,vol. 2, pp. 907- 916 ,(2001) , 10.1038/NI1001-907
Karin Naehrer, Inês Rodrigues, Prevalence of mycotoxins in feedstuffs and feed surveyed worldwide in 2009 and 2010 Phytopathologia Mediterranea. ,vol. 51, pp. 175- 192 ,(2012) , 10.14601/PHYTOPATHOL_MEDITERR-9693
S LI, Y OUYANG, W DONG, J PESTKA, Superinduction of IL-2 Gene Expression by Vomitoxin (Deoxynivalenol) Involves Increased mRNA Stability☆ Toxicology and Applied Pharmacology. ,vol. 147, pp. 331- 342 ,(1997) , 10.1006/TAAP.1997.8279
Constanze Pietsch, Carsten Schulz, Pere Rovira, Werner Kloas, Patricia Burkhardt-Holm, Organ Damage and Hepatic Lipid Accumulation in Carp (Cyprinus carpio L.) after Feed-Borne Exposure to the Mycotoxin, Deoxynivalenol (DON) Toxins. ,vol. 6, pp. 756- 778 ,(2014) , 10.3390/TOXINS6020756
Ding Yan, Hui-Ren Zhou, Kathryn H Brooks, James J Pestka, Potential role for IL-5 and IL-6 in enhanced IgA secretion by Peyer's patch cells isolated from mice acutely exposed to vomitoxin. Toxicology. ,vol. 122, pp. 145- 158 ,(1997) , 10.1016/S0300-483X(97)00087-5
Y Ouyang, Effects of trichothecene structure on cytokine secretion and gene expression in murine CD4+ T-cells Toxicology. ,vol. 104, pp. 187- 202 ,(1995) , 10.1016/0300-483X(95)03147-8
Constanze Pietsch, Reinhard Vogt, Nadja Neumann, Werner Kloas, Production of nitric oxide by carp (Cyprinus carpio L.) kidney leukocytes is regulated by cyclic 3',5'-adenosine monophosphate. Comparative Biochemistry and Physiology A-molecular & Integrative Physiology. ,vol. 150, pp. 58- 65 ,(2008) , 10.1016/J.CBPA.2008.03.003