Non-hodgkin's lymphoma in a population with or at risk for acquired immunodeficiency syndrome: Indications for intensive chemotherapy

作者: Maria Amelia Bermudez , Kathleen M. Grant , Robert Rodvien , Fredric Mendes

DOI: 10.1016/0002-9343(89)90232-5

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摘要: Abstract purpose: An increased risk of malignancies, including Kaposi's sarcoma and non-Hodgkin's lymphoma, is found in patients infected with the human immunodeficiency virus type 1 (HIV-1). Treatment such may be complicated by their underlying immunodeficiency, especially when aggressive regimens are used. Clinical presentatin treatment outcomes were assessed 31 lymphoma who had or at for infection HIV-1 a single community institution. methods: Lymphomas presented advanced stages involved extranodal sites. Twenty-six received therapy (two radiation, one surgery), total 23 chemotherapy. results: A 52 percent response rate was seen use history opportunistic infections, sarcoma, both impacted negatively on ability to achieve complete . Sixty-four 11 an intensive chemotherapeutic regimen, MACOP-B (methotrexate, Adriamycin, cyclophosphamide, vincristine, prednisone, bleomycin) remissions. Overall median survival chemotherapy seven months. Patients achieving responses 20 conclusion: Our results support wth infection.

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