Theta, mental flexibility, and post-traumatic stress disorder: connecting in the parietal cortex.

摘要: Post-traumatic stress disorder (PTSD) is a mental health injury characterised by re-experiencing, avoidance, numbing and hyperarousal. Whilst the aetiology of relatively well understood, there debate about prevalence cognitive sequelae that manifest in PTSD. In particular, are conflicting reports deficits executive function flexibility. Even less known neural changes underlie such deficits. Here, we used magnetoencephalography to study differences functional connectivity during flexibility task combat-related PTSD (all males, mean age = 37.4, n 18) versus military control 33.05, 19) group. We observed large-scale increases theta group compared controls. The performance was compromised more attentionally-demanding this 'late-stage' hyperconnectivity, concentrated network connections involving right parietal cortex. Furthermore, significant correlations with strength region number cognitive-behavioural outcomes, including measures attention, depression anxiety. These findings suggest atypical coordination synchronisation large scale networks contributes for populations timed, tasks, propensity toward hyperconnectivity may play general role evident disorder.