Multikinase Inhibitor-Induced Hand–Foot Skin Reaction: A Review of Clinical Presentation, Pathogenesis, and Management

摘要: Multikinase inhibitors (MKIs) are targeted cancer therapies designed to inhibit multiple tyrosine kinase pathways responsible for tumor proliferation, growth, and survival. These agents more able target cells possess better safety profiles than conventional chemotherapies. However, MKIs can produce significant cutaneous adverse events, hand-foot skin reaction (HFSR) being the most clinically significant. Although not life threatening, HFSR lead MKI dose modification, interruption, or termination, potentially limiting anti-tumor effect. This article summarizes current knowledge concerning epidemiology, clinical presentation, pathogenesis, histopathology, prognostic implication, evidence-based prophylactic reactive treatment options MKI-induced HFSR. Its high incidence impact on quality of emphasizes great need understand pathogenesis improve management this condition.